Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1.

@article{Gamm2008RegulationOP,
  title={Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1.},
  author={David M Gamm and Lynda S. Wright and Elizabeth E. Capowski and Rebecca L. Shearer and Jason S. Meyer and Hyun-Jung Kim and Bernard L Schneider and John Nicholas Melvan and Clive Niels Svendsen},
  journal={Stem cells},
  year={2008},
  volume={26 12},
  pages={3182-93}
}
During development of the central nervous system, stem and progenitor cell proliferation and differentiation are controlled by complex inter- and intracellular interactions that orchestrate the precise spatiotemporal production of particular cell types. Within the embryonic retina, progenitor cells are located adjacent to the retinal pigment epithelium (RPE), which differentiates prior to the neurosensory retina and has the capacity to secrete a multitude of growth factors. We found that… CONTINUE READING