Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor.

Abstract

Killifish survive and reproduce in the New Bedford Harbor (NBH) in Massachusetts (MA), USA, a site severely contaminated with polychlorinated biphenyls (PCBs) for decades. Levels of 22 different PCB congeners were analyzed in liver from killifish collected in 2008. Concentrations of dioxin-like PCBs in liver of NBH killifish were ∼400 times higher, and the… (More)
DOI: 10.1016/j.aquatox.2014.12.010

Topics

8 Figures and Tables

Cite this paper

@article{Grns2015RegulationOP, title={Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor.}, author={Johanna Gr{\"a}ns and Britt Wassmur and Mar{\'i}a Fern{\'a}ndez-Santoscoy and Juliano Zanette and Bruce R. Woodin and Sibel I. Karchner and Diane E. Nacci and Denise M. Champlin and Saro Jayaraman and Mark E Hahn and John J. Stegeman and Malin C. Celander}, journal={Aquatic toxicology}, year={2015}, volume={159}, pages={198-207} }