Regulation of pre-T-cell development

  title={Regulation of pre-T-cell development},
  author={Tarik Moeroey and Holger Karsunky},
  journal={Cellular and Molecular Life Sciences CMLS},
One important pillar of cellular immune defense in mammals is the T-lymphoid compartment which produces cells that are able to specifically recognize foreign peptide antigens through a membrane-bound receptor. These T-cells can trigger a variety of defense mechanisms upon antigen stimulation ranging from the production of potent cytokines to the direct killing of virus-infected cells. The production of such highly specialized T-cells takes place in the thymus and requires a stringent process of… CONTINUE READING


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