Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1

@inproceedings{Kimelman2017RegulationOP,
  title={Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1},
  author={David Kimelman and Natalie L Smith and Jason Kuan Han Lai and Didier Y R Stainier},
  booktitle={eLife},
  year={2017}
}
The vertebrate embryo undergoes a series of dramatic morphological changes as the body extends to form the complete anterior-posterior axis during the somite-forming stages. The molecular mechanisms regulating these complex processes are still largely unknown. We show that the Hippo pathway transcriptional coactivators Yap1 and Wwtr1 are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating… CONTINUE READING