Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange.

@article{Nunnari1987RegulationOP,
  title={Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange.},
  author={Jodi M. Nunnari and M G Repaske and Sue Brandon and Edward J. Cragoe and Lee E. Limbird},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 25},
  pages={12387-92}
}
Previous reports from this laboratory have demonstrated that alpha 2-adrenergic receptors accelerate Na+/H+ exchange in NG108-15 neuroblastoma X glioma cells and evoke platelet secretion via a pathway involving Na+/H+ exchange. The present studies were designed to examine whether agents that interact with Na+/H+ antiporters also might influence alpha 2-adrenergic receptor-ligand interactions. We observed that Na+ decreases receptor affinity for the agonists epinephrine, norepinephrine, and… CONTINUE READING

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