Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications.

  title={Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications.},
  author={Lianhua Piao and Kyoko Fujioka and Makoto Nakakido and Ryuji Hamamoto},
  journal={Frontiers in bioscience},
The poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribosyl)ation, a post-translational modification of proteins. This  consists of the attachment of mono- or poly-adenosine diphosphate (ADP)-ribose units from nicotinamide adenine dinucleotide (NAD+) to specific polar residues of target proteins. PARP1 is the most abundant and best-characterized member of the family of PARP enzymes. PARP1 plays key roles in DNA repair, as well as a wide variety of cellular processes, including… 

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