Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.

@article{Berlanga2006RegulationOP,
  title={Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.},
  author={Juan Jos{\'e} Berlanga and Alexis Baass and Nahum Sonenberg},
  journal={RNA},
  year={2006},
  volume={12 8},
  pages={1556-68}
}
The 5' cap and 3' poly(A) tail of eukaryotic mRNAs act synergistically to enhance translation. This synergy is mediated via interactions between eIF4G (a component of the eIF4F cap binding complex) and poly(A) binding protein (PABP). Paip2 (PABP-interacting protein 2) binds PABP and inhibits translation both in vitro and in vivo by decreasing the affinity of PABP for polyadenylated RNA. Here, we describe the functional characteristics of Paip2B, a Paip2 homolog. A full-length brain cDNA of… CONTINUE READING

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