Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids

  title={Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids},
  author={Mark Linch and Marta Sanz-Garc{\'i}a and Carine Ross{\'e} and Philippe Riou and Nick Peel and Claus B. Madsen and Erik Sahai and Julian Downward and Asim A. Khwaja and Christian Dillon and Jon Roffey and Angus J. M. Cameron and Peter J Parker},
Protein kinase C iota (PKCι), a serine/threonine kinase required for cell polarity, proliferation and migration, is commonly up- or downregulated in cancer. PKCι is a human oncogene but whether this is related to its role in cell polarity and what repertoire of oncogenes acts in concert with PKCι is not known. We developed a panel of candidate oncogene expressing Madin-Darby canine kidney (MDCK) cells and demonstrated that H-Ras, ErbB2 and phosphatidylinositol 3-kinase transformation led to non… CONTINUE READING


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