Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.

  title={Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.},
  author={Shannon M. Buckley and Beatriz Aranda-Orgilles and Alexandros Strikoudis and Eftychia Apostolou and Evangelia Loizou and Kelly Moran-Crusio and Charles L. Farnsworth and Antonius A. Koller and Ramanuj Dasgupta and J. C. da Silva and Matthias Stadtfeld and Konrad Hochedlinger and Emily I. Chen and Iannis Aifantis},
  journal={Cell stem cell},
  volume={11 6},
Although transcriptional regulation of stem cell pluripotency and differentiation has been extensively studied, only a small number of studies have addressed the roles for posttranslational modifications in these processes. A key mechanism of posttranslational modification is ubiquitination by the ubiquitin-proteasome system (UPS). Here, using shotgun proteomics, we map the ubiquitinated protein landscape during embryonic stem cell (ESC) differentiation and induced pluripotency. Moreover, using… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 83 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…