Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.

@article{Buckley2012RegulationOP,
  title={Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.},
  author={Shannon M. Buckley and Beatriz Aranda-Orgilles and Alexandros Strikoudis and Eftychia Apostolou and Evangelia Loizou and Kelly Moran-Crusio and Charles L. Farnsworth and Antonius A. Koller and Ramanuj Dasgupta and J. C. da Silva and Matthias Stadtfeld and Konrad Hochedlinger and Emily I. Chen and Iannis Aifantis},
  journal={Cell stem cell},
  year={2012},
  volume={11 6},
  pages={783-98}
}
Although transcriptional regulation of stem cell pluripotency and differentiation has been extensively studied, only a small number of studies have addressed the roles for posttranslational modifications in these processes. A key mechanism of posttranslational modification is ubiquitination by the ubiquitin-proteasome system (UPS). Here, using shotgun proteomics, we map the ubiquitinated protein landscape during embryonic stem cell (ESC) differentiation and induced pluripotency. Moreover, using… CONTINUE READING
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