Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.

  title={Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.},
  author={Nicolas Humbert and N. Navaratnam and Arnaud Augert and Marco Antonio Ferreira da Costa and S{\'e}bastien Martien and Jing Wang and Dolores L Martinez and Corinne Abbadie and David Carling and Yvan de Launoit and Jes{\'u}s Gil and David Bernard},
  journal={The EMBO journal},
  volume={29 2},
Senescence is an irreversible cell-cycle arrest that is elicited by a wide range of factors, including replicative exhaustion. Emerging evidences suggest that cellular senescence contributes to ageing and acts as a tumour suppressor mechanism. To identify novel genes regulating senescence, we performed a loss-of-function screen on normal human diploid fibroblasts. We show that downregulation of the AMPK-related protein kinase 5 (ARK5 or NUAK1) results in extension of the cellular replicative… CONTINUE READING


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