Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons.

@article{Wang2007RegulationOP,
  title={Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons.},
  author={Ju Hong Wang and Ramana V Gutala and Dongxiao Sun and Jennie Z Ma and Rani C S Sheela and Maharaj K. Ticku and Ming Da Li},
  journal={Alcoholism, clinical and experimental research},
  year={2007},
  volume={31 3},
  pages={357-75}
}
BACKGROUND The higher incidence of smoking among alcoholic subjects suggests the presence of common molecular mechanisms underlying nicotine and alcohol use and abuse. However, these mechanisms are largely unknown. By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and… CONTINUE READING