Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells.

BACKGROUND/AIMS Liver fat-storing cells (FSCs) actively proliferate and secrete extracellular matrix during liver injury. Platelet-derived growth factor (PDGF) is a potent mitogen for cultured FSCs. In the present study, we investigated the regulation of PDGF gene expression and production in cultured human liver FSCs. METHODS PDGF A-chain and B-chain… CONTINUE READING