Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB.

@article{Aizawa2004RegulationOP,
  title={Regulation of platelet-derived growth factor-A chain by Kr{\"u}ppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB.},
  author={Kenichi Aizawa and Toru Suzuki and Nanae Kada and Atsushi Ishihara and Keiko Kawai-Kowase and Takayoshi Matsumura and Kana Sasaki and Yoshiko Munemasa and Ichiro Manabe and Masahiko Kurabayashi and Tucker Collins and Ryozo Nagai},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 1},
  pages={
          70-6
        }
}
The transcription factor Krüppel-like factor 5 (KLF5) and its genetically downstream target gene platelet-derived growth factor-A (PDGF-A) chain are key factors in regulation of cardiovascular remodeling in response to stress. We show that KLF5 mediates a novel distinct delayed persistent induction of PDGF-A chain in response to the model agonist, phorbol ester, through a cis-element previously shown to mediate phorbol ester induction on to PDGF-A chain through the early growth response factor… CONTINUE READING
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