Regulation of platelet biogenesis: insights from the May-Hegglin anomaly and other MYH9-related disorders.

Abstract

Megakaryocyte (MK) maturation culminates in release of blood platelets through proplatelet extensions. MKs presumably delay elaborating proplatelets until synthesis of platelet constituents is complete. Recent insights from investigation of a classic human congenital macrothrombocytopenia, the May-Hegglin anomaly, and related MYH9-associated disorders shed… (More)
DOI: 10.1111/j.1538-7836.2009.03425.x

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