Regulation of platelet activation and thrombus formation by reactive oxygen species

@inproceedings{Qiao2018RegulationOP,
  title={Regulation of platelet activation and thrombus formation by reactive oxygen species},
  author={Jianlin Qiao and Jane F Arthur and Elizabeth E Gardiner and Robert K Andrews and Lingyu Zeng and Kailin Xu},
  booktitle={Redox biology},
  year={2018}
}
Reactive oxygen species (ROS) are generated within activated platelets and play an important role in regulating platelet responses to collagen and collagen-mediated thrombus formation. As a major collagen receptor, platelet-specific glycoprotein (GP)VI is a member of the immunoglobulin (Ig) superfamily, with two extracellular Ig domains, a mucin domain, a transmembrane domain and a cytoplasmic tail. GPVI forms a functional complex with the Fc receptor γ-chain (FcRγ) that, following receptor… CONTINUE READING

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