Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor.

@article{Wang1997RegulationOP,
  title={Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor.},
  author={Hongjian Wang and Xiaoda Tan and H Chang and F X Gonzalez-Crussi and Daniel G Remick and Wei Hsueh},
  journal={The Biochemical journal},
  year={1997},
  volume={322 ( Pt 2)},
  pages={603-8}
}
A competitive PCR assay was developed to quantify platelet-activating factor (PAF) receptor (PAF-R) transcripts in rat tissues using a synthetic RNA as a competitor. We found PAF-R mRNA constitutively expressed in the eight organs tested, with the ileum containing the highest concentration [(3.49+/-0.15) x 10(7) molecules/microg of RNA]. Significant but lower levels were also detected in the jejunum, spleen, lungs, kidneys, heart, stomach and liver. Furthermore we defined the regulatory role of… CONTINUE READING

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