Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling.

@article{Pattabiraman2014RegulationOP,
  title={Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling.},
  author={Padmanabhan Paranji Pattabiraman and Rupalatha Maddala and Ponugoti Vasantha Rao},
  journal={Journal of cellular physiology},
  year={2014},
  volume={229 7},
  pages={
          927-42
        }
}
Glaucoma, a prevalent blinding disease is commonly associated with increased intraocular pressure due to impaired aqueous humor (AH) drainage through the trabecular meshwork (TM). Although increased TM tissue contraction and stiffness in association with accumulation of extracellular matrix (ECM) are believed to be partly responsible for increased resistance to AH outflow, the extracellular cues and intracellular mechanisms regulating TM cell contraction and ECM production are not well defined… CONTINUE READING
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