Regulation of plasma membrane recycling by CFTR.

@article{Bradbury1992RegulationOP,
  title={Regulation of plasma membrane recycling by CFTR.},
  author={Neil A. Bradbury and Tamas Jilling and Gergely Berta and Eric Sorscher and Robert J. Bridges and Kevin L. Kirk},
  journal={Science},
  year={1992},
  volume={256 5056},
  pages={530-2}
}
The gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) is defective in patients with cystic fibrosis. Although the protein product of the CFTR gene has been proposed to function as a chloride ion channel, certain aspects of its function remain unclear. The role of CFTR in the adenosine 3',5'-monophosphate (cAMP)-dependent regulation of plasma membrane recycling was examined. Adenosine 3',5'-monophosphate is known to regulate endocytosis and exocytosis in chloride… CONTINUE READING