Regulation of plasma membrane blebbing by the cytoskeleton

@article{Hagmann1999RegulationOP,
  title={Regulation of plasma membrane blebbing by the cytoskeleton},
  author={J{\"o}rg Hagmann and Max M. Burger and Daniel Dagan},
  journal={Journal of Cellular Biochemistry},
  year={1999},
  volume={73}
}
When neuroblastoma cells are exposed to lysophosphatidic acid (LPA), they undergo a vigorous, but transient blebbing phase. The effect is sensitive to inhibition by staurosporine, KT 5926 (an inhibitor of myosin light chain kinase), and cytochalasin B, suggesting that LPA activates the phosphorylation of myosin light chain and increases the contractile activity of the actomyosin network. Cell contractions increase the intracellular pressure driving bleb formation. Calyculin, an inhibitor of… 

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