Regulation of plasma-membrane-associated sialidase NEU3 gene by Sp1/Sp3 transcription factors.

Abstract

Gene expression of the human plasma membrane-associated sialidase (NEU3), a key enzyme for ganglioside degradation, is relatively high in brain and is modulated in response to many cellular processes, including neuronal cell differentiation and tumorigenesis. We demonstrated previously that NEU3 is markedly up-regulated in various human cancers and showed… (More)
DOI: 10.1042/BJ20100350

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