Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycle.

@article{Choquette1984RegulationOP,
  title={Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycle.},
  author={Denis Choquette and Gabriele Hakim and Adelaida G. Filoteo and Gordon A. Plishker and J. Robert Bostwick and John T. Penniston},
  journal={Biochemical and biophysical research communications},
  year={1984},
  volume={125 3},
  pages={908-15}
}
When the erythrocyte plasma membrane Ca2+ pump is reconstituted into phosphatidylcholine liposomes, the inclusion of small amounts of phosphatidic acid or phosphatidylinositol 4,5-bisphosphate stimulates the enzyme's activity. Other lipids of the phosphatidylinositol cycle (diacylglycerol, phosphatidylinositol) have little effect. The stimulatory effect of phosphatidylinositol 4,5-bisphosphate is greater than that of calmodulin; this lipid also stimulates the plasma membrane Ca2+ ATPase from… CONTINUE READING