Regulation of plasma membrane Ca(2+)-ATPase activity by acetylated tubulin: influence of the lipid environment.

@article{Monesterolo2012RegulationOP,
  title={Regulation of plasma membrane Ca(2+)-ATPase activity by acetylated tubulin: influence of the lipid environment.},
  author={Noelia Edith Monesterolo and Marina Rafaela Amaiden and Alexis Nazareno Campetelli and Ver{\'o}nica Silvina Santander and Carlos Angel Arce and Juan Pi{\'e} and C{\'e}sar Horacio Casale},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1818 3},
  pages={601-8}
}
We demonstrated previously that acetylated tubulin inhibits plasma membrane Ca(2+)-ATPase (PMCA) activity in plasma membrane vesicles (PMVs) of rat brain through a reversible interaction. Dissociation of the PMCA/tubulin complex leads to restoration of ATPase activity. We now report that, when the enzyme is reconstituted in phosphatidylcholine vesicles… CONTINUE READING