Regulation of plasma high-density lipoprotein levels by the ABCA1 transporter and the emerging role of high-density lipoprotein in the treatment of cardiovascular disease.

@article{Brewer2004RegulationOP,
  title={Regulation of plasma high-density lipoprotein levels by the ABCA1 transporter and the emerging role of high-density lipoprotein in the treatment of cardiovascular disease.},
  author={Hollis B Brewer and Alan T Remaley and Edward B. Neufeld and Federica Basso and Charles Joyce},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2004},
  volume={24 10},
  pages={1755-60}
}
High-density lipoproteins (HDL) protect against cardiovascular disease. HDL removes and transports excess cholesterol from peripheral cells to the liver for removal from the body. HDL also protects low-density lipoproteins (LDL) from oxidation and inhibits expression of adhesion molecules in endothelial cells, preventing monocyte movement into the vessel wall. The ABCA1 transporter regulates intracellular cholesterol levels in the liver and in peripheral cells by effluxing excess cholesterol to… CONTINUE READING