Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review.

@article{Ahmed2000RegulationOP,
  title={Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review.},
  author={Adeeba Ahmed and Caroline Dunk and Shakil Ahmad and Asud Khaliq},
  journal={Placenta},
  year={2000},
  volume={21 Suppl A},
  pages={S16-24}
}
Morphological studies show poor placental vascular development and an increase in the mitotic index of cytotrophoblast cells in intrauterine growth restriction (IUGR). We hypothesized that the reported relatively high oxygen level in the intervillous space in contact with IUGR placental villi will limit angiogenesis by changes in vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) expression and function. Western immunoblot analysis demonstrates a diametric expression of… CONTINUE READING

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