Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor.

@article{Kim2002RegulationOP,
  title={Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor.},
  author={Min Sung Kim and Min Kyu Hur and Young June Son and Jae-Il Park and Sang Young Chun and Angela Valentina D'elia and Giuseppe Damante and Sehyung Cho and Kyungjin Kim and Byung Ju Lee},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 39},
  pages={
          36863-71
        }
}
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an important hypophysiotrophic factor as well as a regulator for immune, reproductive, and neural tissues. We recently found that TTF-1, a homeodomain-containing transcription factor essential for the development of the fetal diencephalon, is postnatally expressed in the hypothalamic area and plays a transcription regulatory role for certain neurohormones. Based on the similarity of synthesis sites between PACAP and TTF-1 and… CONTINUE READING

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