Regulation of phytohemagglutinin-induced bovine lymphocyte blastogenesis by leukotrienes.

@article{Atluru1986RegulationOP,
  title={Regulation of phytohemagglutinin-induced bovine lymphocyte blastogenesis by leukotrienes.},
  author={D. Atluru and James S Goodwin},
  journal={American journal of veterinary research},
  year={1986},
  volume={47 9},
  pages={1963-6}
}
Leukotriene (LT) B4, a 5-lipoxygenase metabolite of arachidonic acid, is a potent inducer of suppressor cells in phytohemagglutinin-stimulated cultures of bovine peripheral blood mononuclear cells. In contrast, LTC4 and LTD4 have little activity. Incubation of T lymphocytes with LTB4 at concentrations as low as 1 X 10(-12)M rendered these lymphocytes… CONTINUE READING