Regulation of phospholipase isozymes by nuclear factor-kappaB in human gestational tissues in vitro.

@article{Lappas2004RegulationOP,
  title={Regulation of phospholipase isozymes by nuclear factor-kappaB in human gestational tissues in vitro.},
  author={Martha Lappas and Michael J Permezel and Harry M Georgiou and Gregory Rice},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 5},
  pages={2365-72}
}
Phospholipid-derived mediators are implicated in the initiation and progression of human labor and delivery, particularly in relation to infection-induced preterm labor. We previously demonstrated that, in human intrauterine tissues, lipopolysaccharide (LPS)-stimulated nuclear factor-kappaB (NF-kappaB) DNA binding activity, and subsequent cytokine release can be suppressed by sulfasalazine (SASP) concentrations greater than 5 mM. The aim of this study was to elucidate the effect the SASP on… CONTINUE READING

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