Regulation of phosphoinositide-specific phospholipase C.

@article{Rhee2001RegulationOP,
  title={Regulation of phosphoinositide-specific phospholipase C.},
  author={Sue Goo Rhee},
  journal={Annual review of biochemistry},
  year={2001},
  volume={70},
  pages={
          281-312
        }
}
  • S. Rhee
  • Published 2001
  • Chemistry, Medicine
  • Annual review of biochemistry
Eleven distinct isoforms of phosphoinositide-specific phospholipase C (PLC), which are grouped into four subfamilies (beta, gamma, delta, and epsilon), have been identified in mammals. These isozymes catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] to inositol 1,4,5-trisphosphate and diacylglycerol in response to the activation of more than 100 different cell surface receptors. All PLC isoforms contain X and Y domains, which form the catalytic core, as well as… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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