Regulation of phosphoinositide cycle by intracellular sodium in the blood-brain barrier.


In the present study of cerebral microvessels, we report that monensin, a Na+ ionophore, elicits a decrease in 32P radioactivity incorporation into phosphoinositides in cerebral microvessels. In addition, monensin evokes enhanced production of inositol-1-monophosphate (IP) and inositol-1,4-bisphosphate (IP2), together with an increase in the diacylglycerol… (More)


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