Regulation of phosphate-activated glutaminase (PAG) by glutamate analogues

  title={Regulation of phosphate-activated glutaminase (PAG) by glutamate analogues},
  author={Ralph Dawson and David W. Wallace},
  journal={Neurochemical Research},
The ability of structural analogues of glutamate (GLU) to modulate phosphate activated glutaminase (PAG) was assessed in the present series of studies. A number of GLU receptor agonists and antagonists were tested for their ability to inhibit synaptosomal PAG activity. PAG activity was determined by measuring GLU formation from 0.5mM glutamine (GLN) in the presence of 10 mM phosphate. GLU analogues at 5–10 mM were found to significantly inhibit PAG activity. It was determined that PAG… CONTINUE READING


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