Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases

@article{Joannard2000RegulationOP,
  title={Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases},
  author={Florence Joannard and M E Mart{\'i}nez Galisteo and Laurent Corcos and Andr{\'e} Guillouzo and Dominique Lagadic-Gossmann},
  journal={Cell Biology and Toxicology},
  year={2000},
  volume={16},
  pages={325-337}
}
We investigated the involvement of diverse protein kinases and phosphatases in the transduction pathways elicited by phenobarbital (PB), a well-known inducer of some hepatic cytochromes P450 (CYP). Different inhibitors or activators of protein kinases or phosphatases were assessed for their ability to modulate PB-induction of CYP2B and CYP3A mRNA expression. Rat hepatocytes in primary culture were treated with the test compounds one hour prior to, and then continuously, in the absence or… CONTINUE READING

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