Regulation of phagocyte migration and recruitment by Src-family kinases

  title={Regulation of phagocyte migration and recruitment by Src-family kinases},
  author={Anna Baruzzi and Elena Caveggion and Giorgio Berton},
  journal={Cellular and Molecular Life Sciences},
Src-family kinases (SFKs) regulate different granulocyte and monocyte/macrophage responses. Accumulating evidence suggests that members of this family are implicated in signal transduction pathways regulating phagocytic cell migration and recruitment into inflammatory sites. Macrophages with a genetic deficiency of SFKs display marked alterations in cytoskeleton dynamics, polarization and migration. This same phenotype is found in cells with either a lack of SFK substrates and/or interacting… CONTINUE READING


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A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation

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