Regulation of peroxiredoxins by nitric oxide in immunostimulated macrophages.

  title={Regulation of peroxiredoxins by nitric oxide in immunostimulated macrophages.},
  author={Alexandre Diet and Kahina Abbas and C{\'e}cile Bouton and Blanche Guillon and Flora M Tomasello and Simon Fourquet and Michel B. Toledano and J. -C. Drapier},
  journal={The Journal of biological chemistry},
  volume={282 50},
Reactive oxygen species and nitric oxide (NO) are capable of both mediating redox-sensitive signal transduction and eliciting cell injury. The interplay between these messengers is quite complex, and intersection of their signaling pathways as well as regulation of their fluxes requires tight control. In this regard, peroxiredoxins (Prxs), a recently identified family of six thiol peroxidases, are central because they reduce H2O2, organic peroxides, and peroxynitrite. Here we provide evidence… CONTINUE READING

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