Regulation of perioperative immunological changes following laparotomy: effects of biological response modifier (BRM) on surgical stress.

@article{Ooshiro2004RegulationOP,
  title={Regulation of perioperative immunological changes following laparotomy: effects of biological response modifier (BRM) on surgical stress.},
  author={Mitsuru Ooshiro and Yu-i Sugishita and Hiroshi Tanaka and Kazuki Koide and Makoto Nagashima and Ryoji Katoh},
  journal={Immunology letters},
  year={2004},
  volume={93 1},
  pages={33-8}
}
Immune responses have been reported to decline following surgical stress, leading to an increased susceptibility to infection or to the growth of tumors. In this study, we report that pre-operative treatment with the biological response modifier (BRM) polysaccharide Kureha (PSK) can inhibit the decline of immunocompetence during the perioperative period. BALB/c mice were laparotomized, the intestinal tracts were exposed to room air for 1.5 h, and then the abdomens were closed. Six hours after… CONTINUE READING

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