Regulation of peptide-chain elongation in mammalian cells.

@article{Browne2002RegulationOP,
  title={Regulation of peptide-chain elongation in mammalian cells.},
  author={Gareth J. Browne and Christopher G Proud},
  journal={European journal of biochemistry},
  year={2002},
  volume={269 22},
  pages={
          5360-8
        }
}
The elongation phase of mRNA translation is the stage at which the polypeptide is assembled and requires a substantial amount of metabolic energy. Translation elongation in mammals requires a set of nonribosomal proteins called eukaryotic elongation actors or eEFs. Several of these proteins are subject to phosphorylation in mammalian cells, including the factors eEF1A and eEF1B that are involved in recruitment of amino acyl-tRNAs to the ribosome. eEF2, which mediates ribosomal translocation, is… CONTINUE READING
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