Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4

  title={Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4},
  author={S. Sarkar and L. Cooney and P. White and Deborah B Dunlop and J. Endres and J. Jorns and Matthew J. Wasco and D. Fox},
  journal={Arthritis Research & Therapy},
  pages={R158 - R158}
  • S. Sarkar, L. Cooney, +5 authors D. Fox
  • Published 2009
  • Medicine
  • Arthritis Research & Therapy
  • IntroductionInterleukin (IL)-17 plays an important role in the pathogenesis of rheumatoid arthritis and the mouse model collagen-induced arthritis (CIA). Interferon(IFN)-γ and IL-4 have been shown to suppress Th17 development in vitro, but their potential immunoregulatory roles in vivo are uncertain. The goals of this study were to determine the relationship between Th17 responses and disease severity in CIA and to assess regulation of IL-17 by endogenous IFN-γ and IL-4.MethodsDBA1/LacJ mice… CONTINUE READING
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