Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae.

@article{Casey1992RegulationOP,
  title={Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae.},
  author={W. Casey and G. Keesler and L. W. Parks},
  journal={Journal of bacteriology},
  year={1992},
  volume={174 22},
  pages={
          7283-8
        }
}
Using yeast strains with null mutations in structural genes which encode delta-aminolevulinic acid synthetase (HEM1), isozymes of 3-hydroxy-3-methylglutaryl coenzyme A (HMG1 and HMG2), squalene epoxidase (ERG1), and fatty acid delta 9-desaturase (OLE1), we were able to determine the effect of hemes, sterols, and unsaturated fatty acids on both sterol production and the specific activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in Saccharomyces cerevisiae. We found that the HMGR… Expand
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