Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells.

@article{Clarke1993RegulationOP,
  title={Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells.},
  author={Bart L Clarke and Christian Hassager and Lorraine A. Fitzpatrick},
  journal={Endocrinology},
  year={1993},
  volume={132 3},
  pages={
          1168-75
        }
}
The purpose of this study was to evaluate regulation of PTH secretion by protein kinase-C (PKC) in adult bovine parathyroid cells. Extracellular calcium (Ca2+e) is the main physiological regulator of PTH secretion. Putative second messengers include intracellular calcium (Ca2+i), cAMP, inositol trisphosphate, and diacylglycerol (DAG). Both DAG and Ca2+i activate PKC. Certain phorbol esters mimic the effect of DAG and cause prolonged stimulation of PKC. The stimulatory phorbol esters 12-O… Expand
9 Citations
Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells
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TLDR
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Structure-function relationship of the extracellular calcium-sensing receptor.
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A significant number of children with conotruncal cardiac defects have normocalcemia and a normal constitutive level of parathyroid hormone but deficient parathyro hormone secretory reserve; about 30% also have 22q11 deletions, which may put them at risk for the later development of hypocalcemic hypoparathyroidism. Expand
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A 58-year-old female dialysis patient was admitted to the Nephrology Department at the Hopital Necker because of severe secondary hyperparathyroidism, which led to cessation of the administration of vitamin D derivatives. Expand