Regulation of parathyroid hormone-related peptide gene expression by estrogen in GH4C1 rat pituitary cells has the pattern of a primary response gene.

@article{Holt1994RegulationOP,
  title={Regulation of parathyroid hormone-related peptide gene expression by estrogen in GH4C1 rat pituitary cells has the pattern of a primary response gene.},
  author={Elizabeth H. Holt and C Lu and Barbara E Dreyer and Priscilla S. Dannies and Arthur E. Broadus},
  journal={Journal of neurochemistry},
  year={1994},
  volume={62 4},
  pages={1239-46}
}
The parathyroid hormone-related peptide (PTHrP) gene has been reported to be subject to a wide variety of physiological and pharmacological controls. Two distinct patterns of PTHrP mRNA response have been recognized, one characterized by a prolonged or plateau response lasting many hours to days and the second characterized by rapid induction-deinduction kinetics and lasting 1 to several hours. The kinetics of the second pattern are similar to those displayed by primary response genes like… CONTINUE READING