Regulation of pancreatic amylase and lipase gene expression by diet and insulin in diabetic rats.

@article{Tsai1994RegulationOP,
  title={Regulation of pancreatic amylase and lipase gene expression by diet and insulin in diabetic rats.},
  author={Aileen Tsai and Mitra R. Cowan and David G. Johnson and Patsy M. Brannon},
  journal={The American journal of physiology},
  year={1994},
  volume={267 4 Pt 1},
  pages={G575-83}
}
Although insulin has been proposed to mediate the dietary regulation of pancreatic amylase, its interaction with diet in the regulation of amylase and lipase is not well understood and was examined in diabetic rats fed diets high in carbohydrate (HC), protein (HP), or fat (HF) and treated with insulin. Diabetes, independent of diet, decreased amylase content (97%; P < 0.0001) and mRNA (90%; P < 0.0001), but insulin only restored amylase content and mRNA to respective dietary control values… CONTINUE READING