Regulation of p53 localization and activity by Ubc13.

  title={Regulation of p53 localization and activity by Ubc13.},
  author={Aaron Laine and Ivan Topisirovic and Dayong Zhai and John C. Reed and Katherine Lb Borden and Ze'ev A Ronai},
  journal={Molecular and cellular biology},
  volume={26 23},
The abundance and activity of p53 are regulated largely by ubiquitin ligases. Here we demonstrate a previously undisclosed regulation of p53 localization and activity by Ubc13, an E2 ubiquitin-conjugating enzyme. While increasing p53 stability, Ubc13 decreases p53 transcriptional activity and increases its localization to the cytoplasm, changes that require its ubiquitin-conjugating activity. Ubc13 elicits K63-dependent ubiquitination of p53, which attenuates Hdm2-induced polyubiquitination of… CONTINUE READING