Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells

@article{Fraser2006RegulationOP,
  title={Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells},
  author={Malcolm Fraser and Stephen L. Chan and Ronald Ray Fiscus and Benjamin K. -T. Tsang},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={2203-2212}
}
Dysregulated apoptosis plays a critical role in the development of a number of aberrant cellular processes, including tumorigenesis and chemoresistance. However, the mechanisms that govern the normal apoptotic program are not completely understood. Soluble guanylyl cyclase (sGC) and cyclic guanosine monophosphate (cGMP) promote mammalian cell viability via an unknown mechanism and p53 status is a key determinant of cell fate in human ovarian cancer cells. Whether an interaction exists between… CONTINUE READING
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