Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

  title={Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2},
  author={Thomas G. Hofmann and A. M{\"o}ller and H. Sirma and H. Zentgraf and Y. Taya and W. Dröge and H. Will and M. Schmitz},
  journal={Nature Cell Biology},
  • Thomas G. Hofmann, A. Möller, +5 authors M. Schmitz
  • Published 2002
  • Biology, Medicine
  • Nature Cell Biology
  • Transcriptional activity of p53, a central regulatory switch in a network controlling cell proliferation and apoptosis, is modulated by protein stability and post-translational modifications including phosphorylation and acetylation. Here we demonstrate that the human serine/threonine kinase homeodomain-interacting protein kinase-2 (HIPK2) colocalizes and interacts with p53 and CREB-binding protein (CBP) within promyelocytic leukaemia (PML) nuclear bodies. HIPK2 is activated by ultraviolet (UV… CONTINUE READING
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