Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

@article{Hofmann2002RegulationOP,
  title={Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2},
  author={Thomas G. Hofmann and A. M{\"o}ller and H. Sirma and H. Zentgraf and Y. Taya and W. Dröge and H. Will and M. Schmitz},
  journal={Nature Cell Biology},
  year={2002},
  volume={4},
  pages={1-10}
}
  • Thomas G. Hofmann, A. Möller, +5 authors M. Schmitz
  • Published 2002
  • Biology, Medicine
  • Nature Cell Biology
    • Transcriptional activity of p53, a central regulatory switch in a network controlling cell proliferation and apoptosis, is modulated by protein stability and post-translational modifications including phosphorylation and acetylation. Here we demonstrate that the human serine/threonine kinase homeodomain-interacting protein kinase-2 (HIPK2) colocalizes and interacts with p53 and CREB-binding protein (CBP) within promyelocytic leukaemia (PML) nuclear bodies. HIPK2 is activated by ultraviolet (UV… CONTINUE READING
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    ncbi.nlm.nih.gov
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    Background Citations
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    Methods Citations
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    Results Citations
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    576 Citations
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    References

    SHOWING 1-10 OF 52 REFERENCES
    Deacetylation of p53 modulates its effect on cell growth and apoptosis
    • 750
    Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
    • 2,476
    p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53
    • 1,164
    Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
    • 378
    • PDF
    Mdm2 promotes the rapid degradation of p53
    • 4,002
    p300/CBP‐mediated p53 acetylation is commonly induced by p53‐activating agents and inhibited by MDM2
    • 525
    Stress Signals Utilize Multiple Pathways To Stabilize p53
    • 381
    • PDF
    DNA damage activates p53 through a phosphorylation-acetylation cascade.
    • 1,190
    • PDF
    Regulation of p53 stability by Mdm2
    • 3,146
    Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation
    • 681
    • PDF