Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium.

@article{Donjerkovi1999RegulationOP,
  title={Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium.},
  author={D Donjerkovi{\'c} and Lilin Zhang and David G. W. Scott},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1999},
  volume={10 10},
  pages={695-704}
}
IgM cross-linking induces G1 arrest and apoptosis in murine B-lymphoma cells. It prevents pRb phosphorylation by decreasing cyclin-dependent kinase 2 activity via the up-regulation of cyclin kinase inhibitor p27Kip1. Anti-IgM also causes an increase in cytosolic free calcium and a loss of c-myc mRNA and protein. This down-regulation of c-Myc is prevented by CD40L, which rescues cells from anti-IgM-induced apoptosis. In this study, we addressed the mechanism(s) of anti-IgM-induced p27Kip1… CONTINUE READING