Regulation of p21Waf1 expression and TNFalpha biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: involvement of JNK and ERK pathways.

@article{Debbas2007RegulationOP,
  title={Regulation of p21Waf1 expression and TNFalpha biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: involvement of JNK and ERK pathways.},
  author={Victor Debbas and Roberto J Arai and Simone Ferderbar and Fernanda Schindler and Arnold Stern and Hugo P Monteiro},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={363 4},
  pages={965-70}
}
Oxidative modifications of proteins are fundamental biochemical events that regulate cellular signaling, protein expression, and function. The redox status is balanced by reductants in which GSH plays a major role. This study investigated whether or not p21Waf1 expression and TNFalpha biosynthesis in macrophage differentiation/activation were regulated by GSH modulators and whether or not the JNK and ERK pathway were involved. We observed an increase of p21Waf1 expression and TNFalpha… CONTINUE READING

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