Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)

  title={Regulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)},
  author={N. Kumar and A. Kar},
  journal={IOSR Journal of Pharmacy and Biological Sciences},
  • N. Kumar, A. Kar
  • Published 2013
  • Chemistry
  • IOSR Journal of Pharmacy and Biological Sciences
Hitherto unknown effects of Pyrroloquinoline quinone (PQQ) in 6-n-propyl-2-thiouracil (PTU)- induced oxidative stress and lipid peroxidation were investigated in adult mice. Animals received either PTU (0.05% in drinking water) alone for 5 weeks or PTU + three different concentrations of PQQ, after which alterations in tissue lipid peroxidation (LPO) and in enzymatic activities of superoxide dismutase (SOD) and catalase (CAT) and in glutathione (GSH) content were evaluated in two different… Expand
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