Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem.

  title={Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem.},
  author={Enni Markkanen and Ulrich H{\"u}bscher and Barbara van Loon},
  journal={Cell cycle},
  volume={11 6},
Reactive oxygen species (ROS) constantly attack DNA. One of the best-characterized oxidative DNA lesions is 7,8-dihydro-8-oxoguanine (8-oxo-G). Many human diseases, such as cancer and neurodegenerative disorders, have been correlated with oxidative DNA damage. In the last few years, DNA polymerase (Pol) λ, one of the 15 cellular Pols, has been identified to play an important role in performing accurate translesion synthesis over 8-oxo-G. This is eminently important, since normally faithful… CONTINUE READING


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