Regulation of osteogenesis by fetuin.

  title={Regulation of osteogenesis by fetuin.},
  author={Christoph Binkert and Michael Demetriou and Balram Sukhu and Melanie Szweras and Howard C. Tenenbaum and J. W. Dennis},
  journal={The Journal of biological chemistry},
  volume={274 40},
Osteoporosis is a common problem of aging and results from a failure of homeostatic mechanisms to regulate osteogenesis and mineralization. Bovine and human forms of fetuin glycoprotein bind to the transforming growth factor (TGF)-beta/BMP (bone morphogenic protein) cytokines and block their osteogenic activity in cell culture assays (Demetriou, M., Binkert, C., Sukhu, B., Tenenbaum, H. C., and Dennis, J. W. (1996) J. Biol. Chem. 271, 12755-12761). Fetuin is a prominent serum glycoprotein and a… CONTINUE READING
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