Regulation of osteoclastogenesis by gap junction communication.

  title={Regulation of osteoclastogenesis by gap junction communication.},
  author={Stephen F Matemba and Anita Lie and Maria Ransj{\"o}},
  journal={Journal of cellular biochemistry},
  volume={99 2},
Receptor activator of NF-kappaB ligand (RANKL) is crucial in osteoclastogenesis but signaling events involved in osteoclast differentiation are far from complete and other signals may play a role in osteoclastogenesis. A more direct pathway for cellular crosstalk is provided by gap junction intercellular channel, which allows adjacent cells to exchange second messengers, ions, and cellular metabolites. Here we have investigated the role of gap junction communication in osteoclastogenesis in… CONTINUE READING


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