Regulation of osteoclast function

  title={Regulation of osteoclast function},
  author={Ichiro Nakamura and Naoyuki Takahashi and Eijiro Jimi and Nobuyuki Udagawa and Tatsuo Suda},
  journal={Modern Rheumatology},
Osteoclasts are terminally differentiated multinucleated cells that are the principal resorptive cells of bone, playing a central role in the formation of the skeleton and regulation of its mass. The molecular events involved in the differentiation and function of osteoclasts had not been clarified for a long time. Over the past two decades, several novel approaches have been developed and adopted to investigate osteoclast biology. In the present review, we would like to update recent progress… 

The unique function of p130Cas in regulating the bone metabolism.

Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts

It is found that ninjurin1 (Ninj1) expression is dynamically regulated during osteoclastogenesis and that Ninj1−/− mice exhibit increased trabecular bone volume owing to impaired OC development and analysis of publicly available microarray data sets revealed a potent correlation between high NINJ1 expression and destructive bone disorders in humans.

Deguelin inhibits RANKL‐induced osteoclastogenesis in vitro and prevents inflammation‐mediated bone loss in vivo

Findings reveal that deguelin has antiosteoclastic effects in vitro and in vivo and possesses potential as a new therapeutic option for osteolytic bone diseases.

Idelalisib inhibits osteoclast differentiation and pre-osteoclast migration by blocking the PI3Kδ-Akt-c-Fos/NFATc1 signaling cascade

The present results contribute to the understanding of the clinical value of PI3Kδ as a druggable target and the efficacy of related therapeutics including osteoclastogenesis.

Barley Seedling Extracts Inhibit RANKL-Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early-to-Late Stages of Osteoclastogenesis

  • Sik-Won ChoiS. Kim W. Seo
  • Medicine, Biology
    Evidence-based complementary and alternative medicine : eCAM
  • 2017
Barley seedling from natural foods may provide long-term safety and be useful for the prevention or treatment of osteoclast-mediated bone metabolic diseases, including osteoporosis.

Azithromycin suppresses human osteoclast formation and activity in vitro

It is demonstrated that azithromycin inhibits human osteoclast function in vitro, which may account for at least some of the beneficial clinical effects observed with azithroitcin treatment in periodontitis.

Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis

Monocyte chemoattractant protein-1’s role in bone remodelling and bone-related cancers highlights its potential as a novel anti-resorptive and anti-metastatic target.

Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas

Kif1c overexpression restored bone resorption subsequent to actin ring formation in p130CasΔOCL−/− osteoclasts but not c‐Src−/+ osteoclast, suggesting that Kif1C regulates osteoclastic bone resOrption in the downstream of p130 Cas.



Regulation of Osteoclast Function

The regulatory mechanisms of osteoclast function are reviewed mainly on the basis of the experimental results obtained in the murine culture system.

Regulatory mechanism of osteoclast activation.

The regulatory mechanism of osteoclast activation is reviewed, suggesting their role in linking the adhesion of osteoclasts to the bone matrix, to cytoskeletal organization, and to the polarization and activation of these cells for bone resorption.

Bone resorption by osteoclasts.

Osteopetrotic mutants have provided a wealth of information about the genes that regulate the differentiation of osteoclasts and their capacity to resorb bone.

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.

Osteoblasts/stromal cells can now be replaced with RANKL and M-CSF in dealing with the whole life of osteoclasts, and new ways to treat several metabolic bone diseases caused by abnormal osteoclast recruitment and functions will be established.

Identification of osteopontin in isolated rabbit osteoclasts.

Tyrosine Phosphorylation of p130Cas Is Involved in Actin Organization in Osteoclasts*

It is suggested that Src-dependent tyrosine phosphorylation of Cas is involved in the adhesion-induced actin organization associated with osteoclast activation.

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

Results indicate that osteoclasts appear in the absence of pp60c-src, but that pp60 c-src expression is required for mature osteoclast to form ruffled borders and resorb bone.

Loss of Cbl‐b Increases Osteoclast Bone‐Resorbing Activity and Induces Osteopenia

  • A. NakajimaA. Sanjay R. Baron
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2009
It is reported that Cbl‐b−/− mice are osteopenic, because of increased bone resorption with little compensating increase in bone formation, suggesting that specific RANKL‐activated mechanisms contribute to the increased rate of differentiation and bone‐resorbing activity.

The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor

Data provide the first indication of a function for the VNR and suggest that cell-cell and cell-extracellular matrix interactions involving integrins may play an important role in bone physiology.